An update on Genomic CDS, a complex ontology for pharmacogenomics and clinical decision support

ABSTRACT. Genetic data can be used to optimize drug treatment based on the genetic profiles of individual patients, thereby reducing adverse drug events and improving the efficacy of pharmacotherapy. The Genomic Clinical Decision Support (Genomic CDS) ontology utilizes Web Ontology Language 2 (OWL 2) reasoning for this task. The ontology serves a clear-cut medical use case that requires challenging OWL 2 DL reasoning. We present an update of the Genomic CDS ontology which covers a significantly larger number of clinical decision support rules and where inconsistencies present in previous versions of the ontology have been removed.